|rel-N-(2-(5-甲氧基-1H-吲哚-3-基)乙基)-5-((3aR,4R,6aS)-2-氧代六氢-1H-噻吩并[3,4-d]咪唑-4-基)戊酰胺|CsnPharm

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CAS No.: 2193462-87-0

rel-N-(2-(5-Methoxy-1H-indol-3-yl)ethyl)-5-((3aR,4R,6aS)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide Catalog No. CSN27872

Melatonin Biotin is compound conjuncted melatonin with biotin.

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描述Melatonin Biotin is compound conjunct melatonin with biotin. Melatonin inhibits the inflammation and apoptosis in rats with diabetic retinopathy by repressing the MAPK (mitogen-activated protein kinase) pathway^[1]. Melatonin application had no significant effect on leptin production in the kidney tissues of diabetic rats^[2]. Melatonin (1.25, 5, 20 mg/kg) protects against AIF(apoptosis-inducing factor)-dependent cell death during APAP (Acetaminophen)-induced acute liver failure through its direct inhibition of hepatic RIP1 (receptor interacting protein 1) and subsequent JNK (c-Jun N-terminal kinase) phosphorylation and mitochondrial Bax translocation^[3]. VD3 (1,25-dihydroxyvitamin D3) combined with Mel (Melatonin) significantly reduced apoptotic and histological alterations when compared with Mel or VD3 alone^[4].
参考文献

[1] Ma Y, Zhao Q, Shao Y, Cao MZ, Zhao M, Wang D. Melatonin inhibits the inflammation and apoptosis in rats with diabetic retinopathy via MAPK pathway. Eur Rev Med Pharmacol Sci. 2019 Aug;23(3 Suppl):1-8
[2] Elis Yildiz S, Deprem T, Karadag Sari E, Bingol SA, Koral Tasci S, Aslan S, Nur G, Sozmen M. Immunohistochemical distribution of leptin in kidney tissues of melatonin treated diabetic rats. Biotech Histochem. 2015 May;90(4):270-7
[3] Liang YL, Zhang ZH, Liu XJ, Liu XQ, Tao L, Zhang YF, Wang H, Zhang C, Chen X, Xu DX. Melatonin protects against apoptosis-inducing factor (AIF)-dependent cell death during acetaminophen-induced acute liver failure. PLoS One. 2012;7(12):e51911
[4] Sinanoglu O, Sezgin G, Ozturk G, Tuncdemir M, Guney S, Aksungar FB, Yener N. Melatonin with 1,25-dihydroxyvitamin D3 protects against apoptotic ischemia-reperfusion injury in the rat kidney. Ren Fail. 2012;34(8):1021-6

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4007 mL
- 12.0037 mL
- 24.0075 mL
- 5 mM
- 0.4801 mL
- 2.4007 mL
- 4.8015 mL
- 10 mM
- 0.2401 mL
- 1.2004 mL
- 2.4007 mL

技术信息

CAS号	2193462-87-0		储存条件	粉末 Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C21H28N4O3S		运输	蓝冰
分子量	416.54		别名

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总药量计算器 ✕

动物实验：给药剂量mg/kg 动物体重g 动物数量只每天给药次给药天

需要的总药量：mg

工作液计算器 ✕

动物实验：给药剂量mg/kg 动物体重g 给药体积μL

您需要配制的工作液浓度为：mg/mL

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